Attention: Autism Science Nerds. One of the best reviews on autism neurology I've read in a while.

[Neonatal RRT]

Four Social Brain Regions, Their Dysfunctions, and Sequelae, Extensively Explain Autism Spectrum Disorder Symptomatology - PMC.

 

[Rocco]

Fascinating information, thank you for sharing that.

 

[FilterFreq]

Now I can say "I lack a filter!" and mean it in two entirely different ways!

 

[Neonatal RRT]

FYI: On my other thread about serotonin, psilocybin, and autism, I added information regarding the role of the anterior cingulate cortex (ACC) which acts as the primary "switchboard" for these 4 major areas of the brain. The ACC is heavily populated with the 5-HT2A receptors (as opposed to 1A, 1B, 1C receptors where SSRIs bind to). Psilocybin breaks down to psilocin in the liver and binds to the 2A receptors in the ACC with a higher affinity than endogenous serotonin, suggesting a therapeutic role for psilocybin in autism.

There appears to be genetic polymorphisms in the serotonin binding and transport system in many autistics, and is why our endogenous serotonin might not be binding as well to our 2A receptors as it should be, leading to many of the common symptoms we have.

The PSIAUT study, which is just beginning, will one of the first to put psilocybin in a therapeutic role for autism.