Is it really so? Personally, I have had bad experiences woth SSRIs as a "cure all" and the "just be more positive approach". I am more prone to bad mood than an average person, however, it has reasons. As you kept on writing about serotonin, I thought you meant being unhappy from not addressing your own needs due to alexythymia, not an actual difference in the receptors. When in fact, you're not, am I right? I am in rather positive mood even in the presence of other problems for a consistent number of years now. I have simply addressed my emotional needs and sensory issues also contributed. Intense stimuli are very unpleasant and constant exposure of course will make you unhappy and anxious. Plenty of people I have talked to who have anxiety disorders have a similar experience of higher sensory sensitivity and being triggered by stimuli that wouldn't trigger an average person. Getting yourself out of the loop often means accepting your own senaitivity. There is nothing wrong with it, it's just different. Just my three cents.
Generally speaking, I agree with this. You have to understand how feelings impact you through observation, it's where "flawed" decisions come from, not a lack of intellectual understanding.
SSRIs work on the 1A receptors, not the 2A. The 2A receptors are found predominantly in the ACC and tend to be "excitatory". The 1A receptors are found downstream and tend to be "inhibitory". I am thinking this is why many autistics either feel awful on SSRIs and/or they simply don't work in the same ways as in neurotypicals due to the relatively low "excitatory" influence of the 2A receptors in many autistics. SSRIs, are attempting to prolong the influence of serotonin by inhibiting the 1A receptors, prolonging the excitation, but it's not addressing the real issue, that is the relatively low 2A receptor density and genetic polymorphisms in the genes regulating serotonin binding and transport.
Psilocybin/psilocin appears to have a higher affinity for binding to our 2A receptors than the endogenous serotonin, and appears to bypass the inherent difficulties in serotonin binding and transport. By mimicking serotonin, it can then trigger the cascade of signals needed for proper functioning in many areas of the brain regulated by the ACC.
My personal experience with alexithymia does not appear to have been significantly affected by my use of low-dose psilocybin. I am thinking this issue is more deeply rooted or perhaps is as a result of some other area of the brain. However, my ability to think more clearly, take in more sensory input, be more empathetic, be in a calm, assertive mood, my executive functioning, all of that has improved significantly to the point where others will comment upon it. My fine motor skills even improve significantly in the sense that I am not so "tensed up". I never really sensed I was "tensed up" until the day that I wasn't, and now I am much more aware of it when driving a car, walking, taking stairs, etc. I thought the motor skills decline was age-related, but after a dose, I am functioning much better. It's those 2A receptors doing their work.
I have never had the courage to try a full dose and go on a "psychedelic trip" which, for some, seems to be one of the most positive, life-changing experiences in their life. I am not sure if that would have any impact upon my alexithymia or not, but it has the potential to by unlocking areas of my brain that appear to be blocked or shut down, as this is the underlying mechanism of high-dose psilocybin, it unlocks all the "gates" that separate one area of the brain from another. One could only speculate.
The information about the serotonin system and more specifically within the context of autism, is to point out that there may be a combination of reasons why many autistics have difficulties with the neuroprocessing of emotions, sensory input, impulse control, and general executive functioning. That ACC appears to be a key part of the brain that controls all of that. PSIAUT study will glean some more information, but my anecdotal experience with psilocybin, as well as the experiences of thousands of other individuals, would suggest that there may be another option for the daily management of autism symptoms.