Yeah, the social isolation and misunderstandings get me all the time. I'm depressed over not being able to find a job, my various and complicated medical conditions, PTSD, an inability to make and maintain deep friendships, the inability to find a partner for a physical relationship, being transgender in a fundamentalist household, etc. In other words, I have PLENTY to be depressed about, and sometimes it really does get to me.
That said, I do try to actively work on my stuff, and have a decent set of people who seem to sometimes actually enjoy my company (sometimes they just tolerate me, but at least they try!). I have activities and routines that bring a smile to my face and an eagerness to my step. When my life feels impossible to continue, I make a concerted effort to find something to be grateful for, and usually I can actually find something. While my depression has been clinically deemed situational, its still depression and it still overwhelms me at times, so I feel for you. All I can say is look for the little pluses, the small positives, the slivers of moments where something is RIGHT in your world when things feel horrible. It really does help.
Hugs to all who deal with this mess (if you accept them)!!!