Tiagabine

[Fino]

So I'm prescribed this rarely used GABA reuptake inhibitor called Tiagabine, but I have issues with histamine. I'm trying to figure out if it increases histamine, but there is much less information on this medication than the more commonly used ones. Here is the only solid information I've found on the subject, but I don't know enough to know what it really means:

"Tiagabine binds to histamine H1, serotonin 5HT1B, benzodiazepine, and chloride channel receptors at concentrations 20 to 400 times those inhibiting the uptake of GABA."

When it says it "binds to histamine H1..." does that mean it increases histamine at the H1 receptor? Or does it mean something else?

Thank you for any insight you may provide!

 

[Au Naturel]

Tiagabine is a heavy duty anticonvulsant. It is used for treating epileptic seizures. If they are using it for anything else, it is off-label. Doesn't mean it won't work, but it hasn't been fully certified for those uses.

https://www.fda.gov/patients/learn-...rstanding-unapproved-use-approved-drugs-label
From Wkipedia:

Antihistamine drugs that bind to H-1 receptors are generally used to treat allergies and allergic rhinitis.

This is a question you should ask the doctor who prescribed it. But it sounds from your description it would have an antihistamine effect.

I found quite a bit on the internet about the drug. Here's a good source:

https://pubmed.ncbi.nlm.nih.gov/?term="Tiagabine"

 

[Fino]

Tiagabine is a heavy duty anticonvulsant. It is used for treating epileptic seizures. If they are using it for anything else, it is off-label. Doesn't mean it won't work, but it hasn't been fully certified for those uses.

https://www.fda.gov/patients/learn-...rstanding-unapproved-use-approved-drugs-label
From Wkipedia:

Antihistamine drugs that bind to H-1 receptors are generally used to treat allergies and allergic rhinitis.

This is a question you should ask the doctor who prescribed it. But it sounds from your description it would have an antihistamine effect.

I found quite a bit on the internet about the drug. Here's a good source:

https://pubmed.ncbi.nlm.nih.gov/?term="Tiagabine"

Thank you very much! Unfortunately, every doctor I've spoken to has never even heard of it. It was my idea to take it based on my own research.