I still feel like I did back in 2006: Confused, despondent, and hopeless as well as helpless.
You'll probably still feel the same way in 2050 unless you decide to do something to improve yourself. Much of it has to do with your mentality and willingness to change. If you avoid your problems, don't listen to advice, blame genetics or other people for your problems (victim mentality), and keep thinking the same way, your life will never get better.
Things you can do to improve your life:
Think positively - It can help you feel better and reduce stress. If you try, you can probably find something positive to think about even in the worst situations. You might not feel less depressed in the short-term but it can greatly help in the long-term if you make it a habit.
Focus on what you can change instead of what you can't.
Identify problems and focus on finding solutions to them instead of lamenting about them.
Set goals and make an effort to accomplish them even when it seems like you will fail.
Socialize often with as many people as you can while trying your best to interpret everything as positively as possible (if you get negative thoughts, ask yourself whether they are true or whether you could be misunderstanding the situation due to a habit of thinking negatively). Your opinion of people you talk to will affect how you feel around them so you're almost always better off thinking positively.
Ask for advice from many people and consider following it to see if it will help (what do you have to lose? how much worse can your life really get?). The more often you are given the same advice, the more likely it's true and the more likely it will help if you follow it.