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Autism and actual brain on why we have social issues?

I agree that at some point we will know more. Not sure if that point is close, though.

The aim of my arguments is related to the OP: that we do not know the cause of ASD, which is the reason there is no diagnostic biomarker. No imaging/blood/genetic study that one can use to say that a person has autism. Nothing that anybody can say about a person as to the effect of you have XYZ and that's why you have problems interacting with other people.
Yes and no. Again, I think there will be, but I don't think it will be from any one test, but some combination of several. An "autism spectrum panel" of tests, if you will. The reason we have the long list of "associations" is because we have studied autistics and found commonality in genetics, epigenetics, anatomy, and physiology. Autism, like many other conditions and syndromes, can be diagnosed medically and/or psychologically, if say, it meets not all, but a majority of the criteria. An example: In my world of neonatal medicine, there is a syndrome or sequence we call VACTERL. If a baby is born with Vertebral, Anal, Cardiac, Thoracic, Esophageal, Renal, and Limb abnormalities, they have VACTERL. However, the presentation is highly variable and if the baby has 5 or 6 out of the 7, it can still be considered VACTERL. So it is with autism, every one of us with diagnosed autism has been tested in some way, psychologically, but despite the commonalities that resulted in the autism diagnosis, the testing results comparing us may be variable, hence, what we call "the spectrum".

So, I am thinking right now, given known common ASD genetic and epigenetic and RNA biomarkers, known common anatomical markers, and known common behavioral components, even though not any one test is conclusive, especially given the inherent variability in presentation, there could be an "autism spectrum panel" made up of several tests (genetic, neuroimaging, neurodiagnostic, and psychological). When I use the term "common", this like saying "most", but not all. One may question the need for this, but in the interest of accuracy and specificity, for scientific knowledge, for personal knowledge, I believe this to be important.

When I said in my initial response that there appears to be a convergence or list of factors that make up the "autistic brain", I would hold that statement to be true, regardless of the truth that not all autistic brains are structurally the same.
 
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I had people actually tell me that my conversation with them is going fine and is perfectly normal, even women told me that. I just can't stop comparing my self to others.
Comparing and attaching a value judgment to the comparison is a very bad thing to do to oneself. You are who you are. Comparing yourself to another person won't change who you are, so there's no point.. Making comparisons to other people leads to narcissism, anger at being shortchanged by fate, or depression over failure to measure up.

Judgmental comparison of the self to others is done to reinforce ego or to reaffirm failure. (Plus the aspects of the comparison are usually something you made up in your mind and not a reflection of reality.) I don't know why humans might want to reaffirm helplessness and failure, but we do. When I was young, "wallowing in self-pity" had a perverse satisfaction to it. Self-pity is you telling yourself there are no goals you are capable of reaching, so there is no point in trying. Poor, poor, pitiful me!

If you insist on comparing yourself to something, set a realistic goal to achieve and measure your progress without making value judgments.

If you compare yourself with others, you may become vain, or bitter, for always there will be greater and lesser persons than yourself. - Desiderata
 

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