there are a few vying for position ,merry Christmas Mr. Lawrence along with any movie portraying Japanese internment camps ,Barbarella ,any movie with animal testing.
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Eraserhead
Eraserhead (1977).
I found it interesting, though.
Many people would get up and leave, partway through.
It requires great: patience and tolerance of idiosyncrasy.
I have to say The Exorcist because I believe it was the first movie that seriously freaked out so many people. And paved the way for other movies trying to create the same effect.